Oxymetholone easily converts into estrogen which causes signs of feminization and the already mentioned water retention, which in turn requires the intake of antiestrogens. The increased water retention, in addition to the aesthetical problems, can be further detrimental since it may cause high blood pressure. In extreme cases the intake of an anti-hypertensive drug may be necessary. Oxymetholone does not convert to DHT. However, it is a potent androgen. Users who experience severe steroid acne caused by Anadrol can get this problem under control by using the prescription drug Accutane. Other possible side effects may include headaches, nausea, vomiting, stomach aches, lack of appetite, insomnia, and diarrhea. The athlete can expect a feeling of "general indisposition" with the in-take of Anadrol which is completely in contrast to Dianabol which conveys a "sense of well-being". The increased aggressiveness is caused by the resulting high level of androgen and occurs mostly when large quantities of testosterone are injected simultaneously with the use of Anadrol. The body's own production of testosterone is considerably reduced since Anadrol has an inhibiting effect on the hypothalamus, which in turn completely reduces or stops the release of GnRH (gonadotropin releasing hormone). For this reason the intake of testosterone-stimulating compounds such as HCG and Clomid is absolutely necessary to maintain the hormone production in the testes. If you notice other effects not listed above, contact your doctor.
Genitourinary effects have included oligospermia and decreased ejaculatory volume. Elderly male patients may experience prostatic enlargement resulting in urinary obstruction. Priapism and excessive stimulation may develop. Female patients may experience virilization, including deepening voice, hirsutism, acne, clitomegaly (not reversible), and menstrual abnormalities. Discontinuation of anabolic steroids at signs of mild virilization may prevent irreversible virilization. Alterations in libido may occur (increased/decreased).[Ref]
Hepatic tumors associated with anabolic steroid use are more vascular than other hepatic tumors and may remain silent until the development of life-threatening abdominal hemorrhage. Peliosis hepatitis may present as mild liver dysfunction, but has resulted in liver failure.[Ref] Hepatic side effects have included life-threatening peliosis hepatitis and hepatic abnormalities such as hepatic neoplasms and hepatocellular carcinomas following prolonged therapy with high doses of anabolic steroids. Tumor regression did not occur in all cases following medication withdrawal. Cholestatic hepatitis, jaundice, and abnormal liver function tests can occur at relatively low dosages.