Almost every week, the FDA removes tainted dietary supplements from the market due to health concerns. For example, in January 2016, the FDA issued an alert about “Pink Bikini and Shorts on the Beach Capsules” from Lucy's Weight Loss System of Arlington, TX. It was found that these weight loss aids contained sibutramine, phenolphthalein, and/or diclofenac, but these ingredients were not declared on the label. Sibutramine can cause increase blood pressure and/or pulse rate in some patients and may present a significant risk for patients with a history of coronary artery disease, congestive heart failure, arrhythmias, or stroke. Phenolphthalein was previously used in over-the-counter (OTC) laxatives, but was removed from the US market. Health risks linked to phenolphthalein could include potentially serious stomach upset, irregular heartbeat, and cancer with long-term use. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) which could lead to serious side effects in patients taking other NSAIDs, with recent heart surgery, or with allergies to NSAIDs. NSAIDs can also lead to stomach bleeding, fatal heart attack or stroke.
The data described below reflect exposure to ALIMTA in 168 patients that were fully supplemented with folic acid and vitamin B12. Median age was 60 years (range 19 to 85 years); 82% were men; 92% were White, 5% were Hispanic or Latino, % were Asian, and <1% were other ethnicities; 54% had KPS of 90-100. The median number of treatment cycles administered was 6 in the ALIMTA/cisplatin fully supplemented group and 2 in the ALIMTA/cisplatin never supplemented group. Patients receiving ALIMTA in the fully supplemented group had a relative dose intensity of 93% of the protocol-specified ALIMTA dose intensity. The most common adverse reaction resulting in dose delay was neutropenia.
The information provided by is not a substitute for professional medical advice, diagnosis or treatment. The views and opinions expressed on the site do not necessarily represent those of Drugwatch. Sponsored by Wilson and Peterson, LLP with offices at 1050 30th Street NW, Washington, . 20007. If you are a legal copyright holder or a designated agent for such and you believe a post on this website falls outside the boundaries of "Fair Use" and legitimately infringes on yours or your client's copyright, we may be contacted concerning copyright matters at: webmaster@